AZD5904
Modify Date: 2024-01-16 16:32:36
AZD5904 structure
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Common Name | AZD5904 | ||
|---|---|---|---|---|
| CAS Number | 618913-30-7 | Molecular Weight | 252.293 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H12N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZD5904AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. |
| Name | AZD 5904 |
|---|---|
| Synonym | More Synonyms |
| Description | AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. |
|---|---|
| Related Catalog | |
| Target |
IC50: 140 nM (human MPO)[1] |
| In Vitro | AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H12N4O2S |
| Molecular Weight | 252.293 |
| Exact Mass | 252.068100 |
| LogP | -1.43 |
| Index of Refraction | 1.704 |
| Storage condition | 2-8℃ |
| 6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- |
| 3-[(2R)-Tetrahydro-2-furanylmethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one |
| AZD5904 |