nalorphine

Modify Date: 2025-08-19 21:51:16

nalorphine structure	Common Name	nalorphine
	CAS Number	62-67-9	Molecular Weight	311.37500
	Density	1.38g/cm3	Boiling Point	493.6ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₁NO₃	Melting Point	208ºC
	MSDS	N/A	Flash Point	252.3ºC

Name	(4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Synonym	More Synonyms

Density	1.38g/cm3
Boiling Point	493.6ºC at 760 mmHg
Melting Point	208ºC
Molecular Formula	C₁₉H₂₁NO₃
Molecular Weight	311.37500
Flash Point	252.3ºC
Exact Mass	311.15200
PSA	52.93000
LogP	1.69220
Index of Refraction	1.699
InChIKey	UIQMVEYFGZJHCZ-SSTWWWIQSA-N
SMILES	C=CCN1CCC23c4c5ccc(O)c4OC2C(O)C=CC3C1C5

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QC7700000

CHEMICAL NAME :: Morphinan-3,6-alpha-diol, 17-allyl-7,8-didehydro-4,5-alpha-epoxy-

CAS REGISTRY NUMBER :: 62-67-9

LAST UPDATED :: 199512

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C19-H21-N-O3

MOLECULAR WEIGHT :: 311.41

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JQ P2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - hallucinations, distorted perceptions Behavioral - excitement

REFERENCE :: PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 8,175,1956

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 71 ug/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - tremor Behavioral - antianxiety

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 15,442,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 474 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 165,112,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 226 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 165,112,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,268,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 492 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - hallucinations, distorted perceptions Behavioral - excitement

REFERENCE :: PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 8,175,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 165,112,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 127 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 165,112,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - hallucinations, distorted perceptions Behavioral - excitement

REFERENCE :: PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 8,175,1956

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 13,369,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 13,369,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - hallucinations, distorted perceptions Behavioral - excitement

REFERENCE :: PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 8,175,1956 *** REVIEWS *** TOXICOLOGY REVIEW PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 8,175,1956

allyl bromide

CAS#:106-95-6

normorphine

CAS#:466-97-7

nalorphine

CAS#:62-67-9

Literature: Merck and Co. Inc. Patent: DE949742 , 1952 ;

17-allyl-4,5α-e...

CAS#:58229-59-7

nalorphine

CAS#:62-67-9

Literature: Olofson,R.A.; Schnur,R.C. Tetrahedron Letters, 1977 , p. 1571 - 1574

4,5α-epoxy-3,6α...

CAS#:57934-01-7

nalorphine

CAS#:62-67-9

Literature: Olofson,R.A.; Schnur,R.C. Tetrahedron Letters, 1977 , p. 1571 - 1574

Precursor 4
CAS#:106-95-6 allyl bromide CAS#:466-97-7 normorphine CAS#:58229-59-7 17-allyl-4,5α-e... CAS#:57934-01-7 4,5α-epoxy-3,6α...
DownStream 0

Name: Compound was evaluated for equilibrium constant, Ke
Source: ChEMBL
Target: N/A
External Id: CHEMBL631528

Name: Narcotic antagonist activity in morphine-dependent monkey by single dose suppression ...
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL3278943

Name: Analgesic activity by mouse writhing test after subcutaneous injection.
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL736266

Name: Narcotic antagonist activity in morphine-dependent monkey by precipitated withdrawl t...
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL3278944

Name: Dose (sc) required for 50% reduction in frequency of writhing in mouse writhing analg...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL737800

Name: Human kappa receptor (Opioid receptors)
Source: IUPHAR-DB
Target: kappa receptor (Opioid receptors) [Homo sapiens]
External Id: 318_Human

Name: Narcotic antagonist activity in sc dosed rat assessed as inhibition of oxymorphone-in...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3255779

Name: Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in tetrac...
Source: ChEMBL
Target: Mas-related G-protein coupled receptor member X2
External Id: CHEMBL5665199

Name: Inhibition of acetic acid induced mouse writhing assay following s.c. administration.
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL736711

Name: Inhibition of morphine-induced mania in sc dosed CD-1 mouse assessed as inhibition of...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3256449

Total 80, Current Page 1 of 8

Nalorphinium

Anthorphine

Antorphine

Antorphin

Nalorfina

Allorphine

Nalorphin

Nalorphine

Antorfin

N-allylnormorphine

Anarcon

N-demethyl-N-allylmorphine

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nalorphine

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

nalorphineBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.