NSC10010 hydrochloride

Modify Date: 2024-04-09 12:39:47

NSC10010 hydrochloride Structure
NSC10010 hydrochloride structure
Common Name NSC10010 hydrochloride
CAS Number 6286-09-5 Molecular Weight 537.13600
Density 1.137g/cm3 Boiling Point 674.2ºC at 760 mmHg
Molecular Formula C31H41ClN4O2 Melting Point N/A
MSDS N/A Flash Point 361.5ºC

 Use of NSC10010 hydrochloride


NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase[1][2].

 Names

Name N,N-Bis(2-methyl-6-methoxy-4-quinaldyl)-1,9-diamino- nonane Dihydrochloride Hydrate

 NSC10010 hydrochloride Biological Activity

Description NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase[1][2].
Related Catalog
References

[1]. Dzeng RK, et al. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol. 2015 Feb;9(2):365-76.  

[2]. Amritansh Bhanot, et al. Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation. Results in Chemistry. Volume 5, January 2023, 100904.

 Chemical & Physical Properties

Density 1.137g/cm3
Boiling Point 674.2ºC at 760 mmHg
Molecular Formula C31H41ClN4O2
Molecular Weight 537.13600
Flash Point 361.5ºC
Exact Mass 536.29200
PSA 68.30000
LogP 8.61970
Index of Refraction 1.632
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