L189
L189 structure
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Common Name | L189 | ||
|---|---|---|---|---|
| CAS Number | 64232-83-3 | Molecular Weight | 246.288 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H10N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of L189L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.IC50 value: 5/9/5 μM (for hLigI/III/IV)Target: DNA ligasein vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation. |
Summary: L189, also known as 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one, has a CAS number of 64232-83-3 and a molecular formula of C11H10N4OS with a molecular weight of 246.288. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.IC50 value: 5/9/5 μM (for hLigI/III/IV)Target: DNA ligasein vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C11H10N4OS |
| Molecular Weight | 246.288 |
| Exact Mass | 246.057526 |
| PSA | 123.19000 |
| LogP | 0.32 |
| Index of Refraction | 1.726 |
| InChIKey | SAKOXVNKDMWWLF-UHFFFAOYSA-N |
| SMILES | Nc1[nH]c(=S)[nH]c(=O)c1N=Cc1ccccc1 |
| Storage condition | 2-8℃ |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6-Amino-5-[(E)-benzylideneamino]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone |
| 6-Amino-5-{[(E)-phenylmethylene]amino}-2-sulfanylpyrimidin-4-ol |
| 6-amino-5-benzylideneamino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one |
| 6-amino-5-(benzylideneamino)-2-sulfanyl-4-pyrimidinol |
| 6-Amino-5-[(E)-benzylideneamino]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one |
| L-189 |
| L189 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the storage conditions for 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: Storage conditions for 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one: 2-8℃. |
| Q: What is the LogP of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: LogP of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is 0.32. |
| Q: What is the InChIKey of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: InChIKey of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is SAKOXVNKDMWWLF-UHFFFAOYSA-N. |
| Q: What is the molecular weight of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: Molecular weight of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is 246.288. |
| Q: What is the SMILES notation of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: SMILES notation of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is Nc1[nH]c(=S)[nH]c(=O)c1N=Cc1ccccc1. |
| Q: What is the Chinese name of 64232-83-3? |
| A: Chinese name of 64232-83-3 is L189. |
| Q: What is the molecular formula of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: Molecular formula of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is C11H10N4OS. |
| Q: What English synonyms does 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one have? |
| A: English synonyms of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one: 6-Amino-5-[(E)-benzylideneamino]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone, 6-Amino-5-{[(E)-phenylmethylene]amino}-2-sulfanylpyrimidin-4-ol, 6-amino-5-benzylideneamino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 6-amino-5-(benzylideneamino)-2-sulfanyl-4-pyrimidinol, 6-Amino-5-[(E)-benzylideneamino]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, L-189, L189. |
| Q: What is the English name of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: The English name of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one. |
| Q: What is the CAS number of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one? |
| A: CAS number of 6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one is 64232-83-3. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |