R162
Modify Date: 2024-01-03 17:34:41
R162 structure
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Common Name | R162 | ||
|---|---|---|---|---|
| CAS Number | 64302-87-0 | Molecular Weight | 264.275 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 459.0±34.0 °C at 760 mmHg | |
| Molecular Formula | C17H12O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 245.5±22.2 °C | |
Use of R162R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1), with anti-cancer properties. |
| Name | R162 |
|---|---|
| Synonym | More Synonyms |
| Description | R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1), with anti-cancer properties. |
|---|---|
| Related Catalog | |
| In Vitro | Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells[1]. |
| In Vivo | R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 459.0±34.0 °C at 760 mmHg |
| Molecular Formula | C17H12O3 |
| Molecular Weight | 264.275 |
| Flash Point | 245.5±22.2 °C |
| Exact Mass | 264.078644 |
| LogP | 4.99 |
| Appearance of Characters | yellow solid |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.659 |
| Storage condition | -20℃ |
| 9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)- |
| 2-Allyl-1-hydroxy-9,10-anthraquinone |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: R162
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: R162
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: R162
- Price: $500.0/100mg $1000.0/250mg $2000.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link:
Price: $106/10mM*1mLinDMSO
Reference only. check more R162 price