Demethylwedelolactone

Modify Date: 2024-01-02 19:22:39

Demethylwedelolactone Structure
Demethylwedelolactone structure
Common Name Demethylwedelolactone
CAS Number 6468-55-9 Molecular Weight 300.220
Density 1.8±0.1 g/cm3 Boiling Point 531.4±35.0 °C at 760 mmHg
Molecular Formula C15H8O7 Melting Point 360ºC
MSDS N/A Flash Point 275.2±25.9 °C

 Use of Demethylwedelolactone


Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell[1][2].

 Names

Name 1,3,8,9-Tetrahydroxy-6H-benzofuro[3,2-c]chromen-6-one
Synonym More Synonyms

 Demethylwedelolactone Biological Activity

Description Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell[1][2].
Related Catalog
Target

IC50: 3.0 μM (trypsin)[1]

References

[1]. Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. 2003 Apr;17(4):420-1.

[2]. Lee YJ, et al. Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur J Med Chem. 2012 Oct;56:361-7.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 531.4±35.0 °C at 760 mmHg
Melting Point 360ºC
Molecular Formula C15H8O7
Molecular Weight 300.220
Flash Point 275.2±25.9 °C
Exact Mass 300.027008
PSA 124.27000
LogP 1.79
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.847
Storage condition 2-8℃

 Safety Information

HS Code 2932999099

 Synthetic Route

~84%

Demethylwedelolactone Structure

Demethylwedelol...

CAS#:6468-55-9

Literature: Chang, Chia-Fu; Yang, Ling-Yi; Chang, Shiao-Wei; Fang, Yu-Ting; Lee, Yean-Jang Tetrahedron, 2008 , vol. 64, # 17 p. 3661 - 3666

~90%

Demethylwedelolactone Structure

Demethylwedelol...

CAS#:6468-55-9

Literature: Tabakovic, Ibro; Grujic, Zdravko; Bejtovic, Zlatko Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 635 - 638

~54%

Demethylwedelolactone Structure

Demethylwedelol...

CAS#:6468-55-9

Literature: Rani, B. S. Uma; Darbarwar, Malleshwar Journal of the Indian Chemical Society, 1986 , vol. 63, p. 1060 - 1062

~%

Demethylwedelolactone Structure

Demethylwedelol...

CAS#:6468-55-9

Literature: Tetrahedron, , vol. 45, p. 6867 - 6874

~%

Demethylwedelolactone Structure

Demethylwedelol...

CAS#:6468-55-9

Literature: Tetrahedron, , vol. 45, p. 6867 - 6874

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,3,8,9-tetrahydroxy-
6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 1,3,8,9-tetrahydroxy-
1,3,8,9-Tetrahydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one
demethylwedelolactone
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