Glucagon (19-29) (human, rat, porcine) trifluoroacetate salt

Modify Date: 2024-01-02 20:01:24

Glucagon (19-29) (human, rat, porcine) trifluoroacetate salt structure	Common Name	Glucagon (19-29) (human, rat, porcine) trifluoroacetate salt
	CAS Number	64790-15-4	Molecular Weight	1352.51000
	Density	1.339 g/cm3	Boiling Point	1828.5ºC at 760 mmHg
	Molecular Formula	C₆₁H₈₉N₁₅O₁₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	1059.6ºC

Use of Glucagon (19-29) (human, rat, porcine) trifluoroacetate salt

Glucagon (19-29), human is a potent and efficient inhibitor of insulin secretion.

Name	h-ala-gln-asp-phe-val-gln-trp-leu-met-asn-thr-oh
Synonym	More Synonyms

Description	Glucagon (19-29), human is a potent and efficient inhibitor of insulin secretion.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Peptides
Target	Insulin secretion[1]
In Vitro	Glucagon (19-29), from 0.1 pM to 1 nM, exerts a potent negative inotropic action. The most striking observation is a 45% increase in the amplitude of cell contractility elicited by the combination of 30 nM glucagon with 1 nM Glucagon (19-29)[3].
In Vivo	Glucagon (19-29), also named Miniglucagon, is the COOH-terminal (19-29) fragment processed from glucagon. Glucagon (19-29) dose-dependently inhibits insulin secretion stimulated by 8.3 M glucose, with no change in the perfusion flow rate. A concentration of 1 nM Glucagon (19-29) has a significant inhibitory effect on a 1 nM glucagon-like peptide 1 (7-36) amide–potentiated insulin secretion[1]. Glucagon (19-29) is a highly potent and efficient inhibitor of insulin release by closing, via hyperpolarization, voltage-dependent Ca2+ channels linked to a pathway involving a pertussis toxin-sensitive G protein[2].
Animal Admin	Rats[1] To test the effect of miniglucagon (Glucagon (19-29)) on stimulated insulin secretion, 8.3 mM glucose is perfused during the experiments, including a 45-min equilibration period, followed by miniglucagon (1, 10, 100, and 1,000 pM) perfused with or without 1 nM tGLP-1. To study the glucagon and miniglucagon secretion, the glucose concentration is switched from 11 to 3 mM after a 45-min stabilization period, and the peptides secreted are measured by radioimmunoassay[1].
References	[1]. Dalle S, et al. Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway. J Biol Chem. 1999 Apr 16;274(16):10869-76. [2]. Dalle S, et al. Miniglucagon (glucagon 19-29): a novel regulator of the pancreatic islet physiology. Diabetes. 2002 Feb;51(2):406-12. [3]. Pavoine C, et al. Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon. Am J Physiol. 1991 May;260(5 Pt 1):C993-9.

Density	1.339 g/cm3
Boiling Point	1828.5ºC at 760 mmHg
Molecular Formula	C₆₁H₈₉N₁₅O₁₈S
Molecular Weight	1352.51000
Flash Point	1059.6ºC
Exact Mass	1351.62000
PSA	582.21000
LogP	2.66020
Index of Refraction	1.596

Miniglucagon (huMan,rat,porcine)

Glucagon (19-29) (human,rat,porcine)

GLUCAGON (19-29),HUMAN

AQDFVQWLMNT

glucagon(19-29

Glucagon (19-29) (huMan,rat,porcine) Miniglucagon (huMan,rat,porcine)

ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR

GLUCAGON (19-29),BOVINE,HUMAN,PORCINE

GLUCAGON (19-29) (HUMAN,BOVINE,PORCINE)

Glucagon (19-29), human

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Glucagon (19-29), human
Price: Click To Check
Purity: 98.0%
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GL Biochem (Shanghai) Ltd.
China
Product Name: AQDFVQWLMNT
Price: $Inquiry/1g
Purity: 98.0%
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Nanjing Peptide Biotech Ltd
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Email: enquiry@dycnchem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: Glucagon (19-29) (human, rat, porcine) trifluoroacetate salt
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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