Bedaquiline (Mixture of DiastereoMers)

Modify Date: 2024-01-11 20:09:47

Bedaquiline (Mixture of DiastereoMers) structure	Common Name	Bedaquiline (Mixture of DiastereoMers)
	CAS Number	654655-80-8	Molecular Weight	555.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₁BrN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bedaquiline (Mixture of DiastereoMers)

(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[1][2].

Name	N-desmethyl BDQ
Synonym	More Synonyms

Description	(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Jun;55(6):483-487. [2]. Sarathy JP, et al. TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Others >> Others

References

[1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Jun;55(6):483-487.

[2]. Sarathy JP, et al. TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.