CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XZ5478400
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CHEMICAL NAME :
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s-Triazolo(5,1-a)isoquinoline, 2-(p-chlorophenyl)-
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CAS REGISTRY NUMBER :
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66535-86-2
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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12
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MOLECULAR FORMULA :
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C16-H10-Cl-N3
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MOLECULAR WEIGHT :
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279.74
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,75,1987
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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75 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
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REFERENCE :
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MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,75,1987 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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4500 ug/kg
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SEX/DURATION :
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female 7 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK) V.3- 1980- Volume(issue)/page/year: 4,237,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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2500 ug/kg
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SEX/DURATION :
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female 4-8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 23,75,1987
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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500 ug/kg
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SEX/DURATION :
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female 20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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JAPRAN Journal of Small Animal Practice. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 23,295,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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500 ug/kg
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SEX/DURATION :
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female 20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK) V.3- 1980- Volume(issue)/page/year: 4,237,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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40 mg/kg
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SEX/DURATION :
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female 4-8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK) V.3- 1980- Volume(issue)/page/year: 4,237,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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40 mg/kg
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SEX/DURATION :
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female 4-8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 5,55,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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70 ug/kg
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SEX/DURATION :
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female 4 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK) V.3- 1980- Volume(issue)/page/year: 4,237,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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125 ug/kg
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SEX/DURATION :
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female 4-8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 5,55,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravaginal
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DOSE :
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15 mg/kg
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SEX/DURATION :
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female 4-6 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK) V.3- 1980- Volume(issue)/page/year: 4,237,1982
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