CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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OK6750000
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CHEMICAL NAME :
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Luteinizing hormone-releasing factor (pig), 6-D-tryptophan-7-(N-methyl-L-leucine)-9-(N- ethyl-L-prolinamide)-10-deglycinamide-
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CAS REGISTRY NUMBER :
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66866-63-5
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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11
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MOLECULAR FORMULA :
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C65-H85-N17-O12
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MOLECULAR WEIGHT :
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1296.67
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
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REFERENCE :
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AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73, 90141 Palermo, Italy) V.1- 1969- Volume(issue)/page/year: 11,113,1980 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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3500 ug/kg
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SEX/DURATION :
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female 1-7 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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30 mg/kg
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SEX/DURATION :
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female 7-12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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3500 ng/kg
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SEX/DURATION :
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female 1-7 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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30 ug/kg
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SEX/DURATION :
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female 7-12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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35 ug/kg
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SEX/DURATION :
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female 1-7 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
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REFERENCE :
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EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 6,1,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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250 ug/kg
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SEX/DURATION :
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female 6 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 29,122,1984
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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50 ug/kg
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SEX/DURATION :
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female 10 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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700 ug/kg
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SEX/DURATION :
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male 20 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
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REFERENCE :
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FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 43,115,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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70 ug/kg
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SEX/DURATION :
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female 1-7 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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6 ug/kg
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SEX/DURATION :
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female 7-12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
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