phenprobamate

Modify Date: 2025-08-22 18:20:13

phenprobamate structure	Common Name	phenprobamate
	CAS Number	673-31-4	Molecular Weight	179.216
	Density	1.1±0.1 g/cm3	Boiling Point	295.5±33.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₃NO₂	Melting Point	101-104℃
	MSDS	N/A	Flash Point	132.5±25.4 °C

Use of phenprobamate

Phenprobamate (3-Phenylpropyl carbamate; MH 532; Proformiphen) is a widely used, centrally acting skeletal muscle relaxant, with sedative and anticonvulsant effects[1].

Name	3-phenylpropyl carbamate
Synonym	More Synonyms

Description	Phenprobamate (3-Phenylpropyl carbamate; MH 532; Proformiphen) is a widely used, centrally acting skeletal muscle relaxant, with sedative and anticonvulsant effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. J X Sun, et al. High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharm Drug Dispos. Jul-Aug 1987;8(4):341-51.

Density	1.1±0.1 g/cm3
Boiling Point	295.5±33.0 °C at 760 mmHg
Melting Point	101-104℃
Molecular Formula	C₁₀H₁₃NO₂
Molecular Weight	179.216
Flash Point	132.5±25.4 °C
Exact Mass	179.094635
PSA	52.32000
LogP	2.16
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.519
InChIKey	CAMYKONBWHRPDD-UHFFFAOYSA-N
SMILES	NC(=O)OCCCc1ccccc1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB9275000

CHEMICAL NAME :: 1-Propanol, 3-phenyl-, carbamate

CAS REGISTRY NUMBER :: 673-31-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-N-O2

MOLECULAR WEIGHT :: 179.24

WISWESSER LINE NOTATION :: ZVO3R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1110 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,856,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,140,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1047,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

HS Code	2924299090

3-Phenylpropan-1-ol

CAS#:122-97-4

Phenyl carbamate

CAS#:622-46-8

~96%

phenprobamate

CAS#:673-31-4

Literature: Ichikawa, Yoshiyasu; Morishita, Yukinori; Kusaba, Shuhei; Sakiyama, Naoto; Matsuda, Yasunori; Nakano, Keiji; Kotsuki, Hiyoshizo Synlett, 2010 , # 12 p. 1815 - 1818

3-Phenylpropan-1-ol

CAS#:122-97-4

phenprobamate

CAS#:673-31-4

Literature: European Journal of Organic Chemistry, , # 5 p. 908 - 911

3-Phenylpropan-1-ol

CAS#:122-97-4

Sodium cyanide

CAS#:143-33-9

phenprobamate

CAS#:673-31-4

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 6 p. 2403 - 2410

Precursor 3
CAS#:122-97-4 3-Phenylpropan-1-ol CAS#:622-46-8 Phenyl carbamate CAS#:143-33-9 Sodium cyanide
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201

Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN

Name: qHTS for Inhibitors of TGF-b
Source: NCGC
Target: Smad3 [Homo sapiens]
External Id: SMAD3101

Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p

Total 395, Current Page 1 of 40

Quamaquil

Extacol

Proformiphen

Carbamic Acid 3-Phenylpropyl Ester

phenprobamate

Nelaxan

3-Phenylpropyl carbamate

Gamaquil

EINECS 211-606-1

MFCD00868163

Eirenal

benzenepropanol

g-Phenylpropyl Carbamate

3-Phenylpropyl hydrogen carbonimidate

Palmita

Ansepron

Benzenepropanol, carbamate

Actiphan

Actozine

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