Vanoxerine

Modify Date: 2024-01-12 07:56:51

Vanoxerine structure	Common Name	Vanoxerine
	CAS Number	67469-69-6	Molecular Weight	450.56300
	Density	1.135g/cm3	Boiling Point	542.7ºC at 760 mmHg
	Molecular Formula	C₂₈H₃₂F₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	282ºC

Use of Vanoxerine

Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).IC50 value:Target: Dopamine reuptake inhibitorAt a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.

Name	vanoxerine
Synonym	More Synonyms

Description	Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).IC50 value:Target: Dopamine reuptake inhibitorAt a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease
References	[1]. Mahmud F, et al. Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue. Chaos. 2011 Jun;21(2):023121. [2]. Lacerda AE, et al. Vanoxerine: cellular mechanism of a new antiarrhythmic. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter

Research Areas >> Neurological Disease

References

[1]. Mahmud F, et al. Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue. Chaos. 2011 Jun;21(2):023121.

[2]. Lacerda AE, et al. Vanoxerine: cellular mechanism of a new antiarrhythmic. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.

Density	1.135g/cm3
Boiling Point	542.7ºC at 760 mmHg
Molecular Formula	C₂₈H₃₂F₂N₂O
Molecular Weight	450.56300
Flash Point	282ºC
Exact Mass	450.24800
PSA	15.71000
LogP	5.19700
Index of Refraction	1.561
Storage condition	2-8℃