GPRP

Modify Date: 2024-01-06 15:48:20

GPRP Structure
GPRP structure
Common Name GPRP
CAS Number 67869-62-9 Molecular Weight 425.48300
Density 1.55 g/cm3 Boiling Point N/A
Molecular Formula C18H31N7O5 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of GPRP


GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2].

 Names

Name gly-pro-arg-pro
Synonym More Synonyms

 GPRP Biological Activity

Description GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2].
Related Catalog
References

[1]. Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50.

[2]. Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7.

 Chemical & Physical Properties

Density 1.55 g/cm3
Molecular Formula C18H31N7O5
Molecular Weight 425.48300
Exact Mass 425.23900
PSA 194.94000
Index of Refraction 1.691
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles30

More Articles
Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.

J. Thromb. Haemost. 12(8) , 1342-52, (2014)

Integrin-linked kinase (ILK) and its associated complex of proteins are involved in many cellular activation processes, including cell adhesion and integrin signaling. We have previously demonstrated ...

Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP.

Blood 126 , 873-9, (2015)

Immune thrombocytopenia (ITP) patients with similarly low platelet counts differ in their tendency to bleed. To determine if differences in platelet function in ITP patients account for this variation...

Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.

J. Biol. Chem. 288(41) , 29621-32, (2013)

Strongly activated "coated" platelets are characterized by increased phosphatidylserine (PS) surface expression, α-granule protein retention, and lack of active integrin αIIbβ3. To study how they are ...

 Synonyms

glycine-proline-arginine-proline
FIBRINOLYSIS INHIBITNG FACTOR
LAUDANO-DOOLITTLE PEPTIDE
GPRP FIBRIN ANTIPOLYMERANT
GPRP
glycyl-L-prolyl-L-arginyl-L-prolin
MFCD00133378
glycyl-prolyl-arginyl-proline
FIBRINOLYSIS INHIBITING FACTOR
M.W. 425.49 C18H31N7O5
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