Poloppin
Modify Date: 2023-03-12 20:58:12
Poloppin structure
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Common Name | Poloppin | ||
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| CAS Number | 683808-78-8 | Molecular Weight | 438.238 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 536.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H15BrF3NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 278.4±30.1 °C | |
Use of PoloppinPoloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays; triggers dose-dependent mitotic arrest with non-congressed chromosomes in human cell lines, preferentially kills cells expressing mutant KRAS (SW48 G12D GI50=5.2 uM, SW48 Wt GI50=13.7 uM), sensitizes mutant KRAS-expressing cells to clinical inhibitors of c-MET. |
| Name | 3-{5-(4-Bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid |
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| Synonym | More Synonyms |
| Description | Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays; triggers dose-dependent mitotic arrest with non-congressed chromosomes in human cell lines, preferentially kills cells expressing mutant KRAS (SW48 G12D GI50=5.2 uM, SW48 Wt GI50=13.7 uM), sensitizes mutant KRAS-expressing cells to clinical inhibitors of c-MET. |
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| References | References 1. Narvaez AJ, et al. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. View Related Products by Target Polo-like Kinase (PLK) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 536.7±50.0 °C at 760 mmHg |
| Molecular Formula | C20H15BrF3NO2 |
| Molecular Weight | 438.238 |
| Flash Point | 278.4±30.1 °C |
| Exact Mass | 437.023804 |
| LogP | 6.08 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.582 |
| 3-{5-(4-Bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid |
| 1H-Pyrrole-2-propanoic acid, 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]- |