Tiotidine
Modify Date: 2024-01-13 18:28:06
Tiotidine structure
|
Common Name | Tiotidine | ||
|---|---|---|---|---|
| CAS Number | 69014-14-8 | Molecular Weight | 312.41800 | |
| Density | 1.5g/cm3 | Boiling Point | 543.6ºC at 760 mmHg | |
| Molecular Formula | C10H16N8S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 282.5ºC | |
Use of TiotidineTiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors[1][2]. |
| Name | 1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine |
|---|---|
| Synonym | More Synonyms |
| Description | Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors[1][2]. |
|---|---|
| Related Catalog | |
| Target |
H2 Receptor:7.3-7.8 (pA2) H1 receptor:<4.5 (pA2) H3 Receptor:4.8 (pA2) |
| In Vitro | Tiotidine competitively antagonizes the positive chronotropic action of histamine with an apparent dissociation constant of 30 μM (23-38 μM). Tiotidine abolishes H2-mediated increases in contractile force leaving H2-mediated negative inotropic responses unopposed. The actions of histamine at the A-V node, manifested by lengthening of the P-R interval and A-V block, are attenuated by 2.5 x 10(-7) M Tiotidine[2]. Tiotidine actually behaves as an inverse agonist in U-937 cells, diminishing basal cAMP levels[3]. |
| References |
| Density | 1.5g/cm3 |
|---|---|
| Boiling Point | 543.6ºC at 760 mmHg |
| Molecular Formula | C10H16N8S2 |
| Molecular Weight | 312.41800 |
| Flash Point | 282.5ºC |
| Exact Mass | 312.09400 |
| PSA | 188.54000 |
| LogP | 1.98258 |
| Index of Refraction | 1.728 |
| ICI 125,211 |
| TIOTIDINE |
| Tiotidinum |
| Tiotidina |