N,N'-Dinitrosopiperazine-d8

Modify Date: 2024-01-10 10:36:33

N,N'-Dinitrosopiperazine-d8 Structure
N,N'-Dinitrosopiperazine-d8 structure
 Common Name N,N'-Dinitrosopiperazine-d8
CAS Number 69340-07-4 Molecular Weight 152.181214224
Density N/A Boiling Point N/A
Molecular Formula C4D8N4O2 Melting Point 175-178°C
MSDS N/A Flash Point N/A

 Use of N,N'-Dinitrosopiperazine-d8


N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].

 Names

Name 1,4-Dinitrosopiperazine-d8

 N,N'-Dinitrosopiperazine-d8 Biological Activity

Description N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Damao Huang, et al. Identification of Novel Signaling Components in N,N'-dinitrosopiperazine-mediated Metastasis of Nasopharyngeal Carcinoma by Quantitative Phosphoproteomics. BMC Cancer. 2014 Apr 5;14:243.  

 Chemical & Physical Properties

Melting Point 175-178°C
Molecular Formula C4D8N4O2
Molecular Weight 152.181214224
Storage condition -20°C Freezer
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