1-Acetyl-3-o-toluyl-5-fluorouracil
Modify Date: 2026-08-21 17:07:30
1-Acetyl-3-o-toluyl-5-fluorouracil structure
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Common Name | 1-Acetyl-3-o-toluyl-5-fluorouracil | ||
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| CAS Number | 71861-76-2 | Molecular Weight | 290.24700 | |
| Density | 1.44g/cm3 | Boiling Point | 408.8ºC at 760 mmHg | |
| Molecular Formula | C14H11FN2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 201.1ºC | |
Use of 1-Acetyl-3-o-toluyl-5-fluorouracil1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent. |
| Name | 1-acetyl-5-fluoro-3-(2-methylbenzoyl)pyrimidine-2,4-dione |
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| Synonym | More Synonyms |
| Description | 1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent. |
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| Related Catalog | |
| In Vivo | Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1]. |
| Animal Admin | Mice: Of the ten groups of tumor bearing mice, subcutaneous administration of 5-fluorouracil or 1-Acetyl-3-o-toluyl-5-fluorouracil is made at a dose of 0.2, 0.4 and 0.6 mmol/kg/d on six groups in the buttock region. In three groups, oil solution of 1-Acetyl-3-o-toluyl-5-fluorouracil is administered orally with a stomach tube at a dose of 0.2, 0.4 and 0.6 mmol/kg/d. The remaining group is used as tumor bearing control. During the period of the experiment, body weight is measured every 3 day and the long and short diameters of the tumor are measured daily[1]. |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Boiling Point | 408.8ºC at 760 mmHg |
| Molecular Formula | C14H11FN2O4 |
| Molecular Weight | 290.24700 |
| Flash Point | 201.1ºC |
| Exact Mass | 290.07000 |
| PSA | 78.14000 |
| LogP | 0.80610 |
| Index of Refraction | 1.609 |
| InChIKey | DRXHAKVGNKHFMB-UHFFFAOYSA-N |
| SMILES | CC(=O)n1cc(F)c(=O)n(C(=O)c2ccccc2C)c1=O |
| Storage condition | 2-8℃ |
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| A-OT |
| 1-Acetyl-5-fluoro-3-(2-methylbenzoyl)-2,4-(1H,3H)-pyrimidinedione |
| N(sub 1)-Acetyl-N(sub 3)-o-toluyl-5-fluorouracil |
| Atofluding |
| 1-Acetyl-3,2-toluyl-5-fluorouracil |
| 2,4(1H,3H)-Pyrimidinedione,1-acetyl-5-fluoro-3-(2-methylbenzoyl) |
| 1-Acetyl-3-o-toluyl-5-fluorouracil |