Leukotriene C4

Modify Date: 2024-01-02 15:55:16

Leukotriene C4 Structure
Leukotriene C4 structure
Common Name Leukotriene C4
CAS Number 72025-60-6 Molecular Weight 625.774
Density 1.2±0.1 g/cm3 Boiling Point 974.3±65.0 °C at 760 mmHg
Molecular Formula C30H47N3O9S Melting Point N/A
MSDS N/A Flash Point 543.1±34.3 °C

 Use of Leukotriene C4


Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. Leukotriene C4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. Leukotriene C4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.

 Names

Name leukotriene C4
Synonym More Synonyms

 Leukotriene C4 Biological Activity

Description Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. Leukotriene C4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. Leukotriene C4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 974.3±65.0 °C at 760 mmHg
Molecular Formula C30H47N3O9S
Molecular Weight 625.774
Flash Point 543.1±34.3 °C
Exact Mass 625.303284
PSA 241.65000
LogP 4.35
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.564

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9143500
CHEMICAL NAME :
Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecat etraenyl)-N-L-gamma-g lutamyl-L- cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))-
CAS REGISTRY NUMBER :
72025-60-6
LAST UPDATED :
198912
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C30-H47-N3-O9-S
MOLECULAR WEIGHT :
625.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
10 nmol/L
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 76,374,1985

 Safety Information

Hazard Codes F: Flammable;T: Toxic;
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 36/37-45
RIDADR UN 1230 3/PG 2

 Synonyms

L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine
7,9,11,14-Eicosatetraenoic acid, 6-[[(2R,3Z)-2-[[(1E,4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino]-3-[(carboxymethyl)imino]-3-hydroxypropyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteinylglycine
leukotriene C1
Leukotriene C4
leucotriene C-1
Leukotriene C4 Lipid Maps MS Standard
Leucotriene C4
(5S,6R,7E,9E,11Z,14Z)-6-({(2R,3Z)-2-{(E)-[(4S)-4-Amino-4-carboxy-1-hydroxybutylidene]amino}-3-[(carboxymethyl)imino]-3-hydroxypropyl}sulfanyl)-5-hydroxy-7,9,11,14-icosatetraenoic acid
LTC4
Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-
leukotrienec
MFCD00151079
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