L-DABA hydrobromide
Modify Date: 2024-01-12 15:02:55
L-DABA hydrobromide structure
|
Common Name | L-DABA hydrobromide | ||
|---|---|---|---|---|
| CAS Number | 73143-97-2 | Molecular Weight | 199.05 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H11BrN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of L-DABA hydrobromideL-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro. |
| Name | (S)-2,4-Diaminobutanoic acid hydrobromide |
|---|---|
| Synonym | More Synonyms |
| Description | L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro. |
|---|---|
| Related Catalog | |
| Target |
IC50: larger than 500 μM (GABA transaminase)[1] |
| In Vitro | The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA hydrobromide is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA hydrobromide. The harmful effect of L-DABA hydrobromide could be abolished by concomitant incubation with L-alanine and L-methionine[1]. Kinetic studies indicates that L-DABA hydrobromide is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA hydrobromide-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA hydrobromide necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[3]. |
| In Vivo | Treatment with L-DABA hydrobromide results in 43.4% reduction of tumor growth[1]. L-DABA hydrobromide is a more effective inhibitor of GABA transaminase in vivo than in vitro[2]. |
| References |
| Molecular Formula | C4H11BrN2O2 |
|---|---|
| Molecular Weight | 199.05 |
| Exact Mass | 198.000381 |
| PSA | 89.34000 |
| LogP | 1.10580 |
|
~%
L-DABA hydrobromide CAS#:73143-97-2 |
| Literature: Jones; Crockett, Alan K. Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7459 - 7462 |
![(2S)-4-amino-2-[(4-methylphenyl)sulfonylamino]butanoic acid structure](https://image.chemsrc.com/caspic/261/62234-29-1.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| (S)-2,4-bis-benzyloxycarbonylamino-butyric acid |
| (S)-2,4-Bis-benzyloxycarbonylamino-buttersaeure |
| (S)-2,4-diamino-butyric acid,hydrobromide |
| (2S)-2,4-Diaminobutanoic acid hydrobromide (1:1) |
| Butanoic acid, 2,4-diamino-, (2S)-, hydrobromide (1:1) |
| (S)-2,4-Diamino-buttersaeure,Hydrobromid |
| N,N'-Cbz-L-2,4-diaminobutanoic acid |
| Z-DAB(Z)-OH |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: L-DABA hydrobromide
- Price: Click To Check
- Purity: 99.11%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: L-DABA hydrobromide
- Price: ￥2930.0/25g
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (S)-2,4-DIAMINOBUTANOIC ACID HYDROBROMIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
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- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: ￥200/100 mg
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