Lithium mupirocin

Modify Date: 2024-01-07 11:38:35

Lithium mupirocin Structure
Lithium mupirocin structure
Common Name Lithium mupirocin
CAS Number 73346-79-9 Molecular Weight 506.56
Density N/A Boiling Point N/A
Molecular Formula C26H43LiO9 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Lithium mupirocin


Mupirocin (BRL-4910A) lithium is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin lithium apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2][3][4][5].

 Names

Name lithium,9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate
Synonym More Synonyms

 Lithium mupirocin Biological Activity

Description Mupirocin (BRL-4910A) lithium is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin lithium apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2][3][4][5].
Related Catalog
References

[1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8.  

[2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70.  

[3]. Vingsbo Lundberg C, et al. Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model. Int J Antimicrob Agents. 2013 Sep. 42(3):272-5.  

 Chemical & Physical Properties

Molecular Formula C26H43LiO9
Molecular Weight 506.56
Exact Mass 500.29900
PSA 146.05000
LogP 2.59250

 Safety Information

RIDADR NONH for all modes of transport

 Articles36

More Articles
Short-term decline in all-cause acquired infections with the routine use of a decontamination regimen combining topical polymyxin, tobramycin, and amphotericin B with mupirocin and chlorhexidine in the ICU: a single-center experience.

Crit. Care Med. 42(5) , 1121-30, (2014)

In a multicenter, placebo-controlled, randomized, double-blind trial, we showed that acquired infections in intubated patients were reduced by the combination of topical polymyxin plus tobramycin and ...

Oral antibiotics versus topical decolonization to prevent surgical site infection after Mohs micrographic surgery--a randomized, controlled trial.

Dermatol. Surg. 39(10) , 1486-93, (2013)

The optimal method of reducing the risk of surgical site infection (SSI) after dermatologic surgery is unclear. Empiric, preoperative antibiotic use is common practice but lacks supporting evidence fo...

Screening for MRSA and isolating carriers doesn't reduce ICU infections.

BMJ 346 , f3581, (2013)

 Synonyms

Lithium mupirocin
Li-MUP
Pseudomonic acid A lithium salt
9-((E)-4-{(2S,3R,4R,5S)-3,4-Dihydroxy-5-[(2S,3S)-3-((1S,2S)-2-hydroxy-1-methyl-propyl)oxiranylmethyl]tetrahydro-pyran-2-yl}-3-methyl-but-2-enoyloxy)nonanoic acid lithium salt
Lithium mupirocin Supplement
Lithium mupirocin solution