Imiclopazine

Modify Date: 2024-01-05 19:28:41

Imiclopazine Structure
Imiclopazine structure
Common Name Imiclopazine
CAS Number 7414-95-1 Molecular Weight 486.07200
Density 1.252g/cm3 Boiling Point 659.8ºC at 760mmHg
Molecular Formula C25H32ClN5OS Melting Point N/A
MSDS N/A Flash Point 352.8ºC

 Use of Imiclopazine


Imiclopazine is a phenothiazine derivative with good sedative, analgesic, antiaggressive and antiemetic effects[1].

 Names

Name Imidazolidone dihydrochloride
Synonym More Synonyms

 Imiclopazine Biological Activity

Description Imiclopazine is a phenothiazine derivative with good sedative, analgesic, antiaggressive and antiemetic effects[1].
Related Catalog
In Vitro Imiclopazine shows multidrug-resistance (MDR)-reversal activity in P388 and P388/ADR cells, with EC50 values of both 200 μM[2].
References

[1]. A Ramu, et al. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol. 1992;30(3):165-73.

[2]. D. Lenke, et al. Pharmacological activity of new phenothiazine and azaphenothiazine derivatives. January 1971, Arzneimittel-Forschung. 21:288-293.

 Chemical & Physical Properties

Density 1.252g/cm3
Boiling Point 659.8ºC at 760mmHg
Molecular Formula C25H32ClN5OS
Molecular Weight 486.07200
Flash Point 352.8ºC
Exact Mass 485.20200
PSA 58.57000
LogP 4.13440

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ0621400
CHEMICAL NAME :
2-Imidazolidinone, 1-(2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-pipe razinyl)ethyl)-3- methyl-, dihydrochloride
CAS REGISTRY NUMBER :
7414-95-1
LAST UPDATED :
198910
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C25-H32-Cl-N5-O-S.2Cl-H
MOLECULAR WEIGHT :
559.05
WISWESSER LINE NOTATION :
T C666 BN ISJ EG B3- AT6N DNTJ D2- AT5NVNTJ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
321 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

 Synonyms

Chlorimpiphenine dihydrochloride
Chorimpiphenine
P-4241
Chlorimiphene dichloride
Ponsital
Imiclopazine hydrochloride
Chlorimphenine hydrochloride
Imiclopazine dihydrochloride
Asta p 4241