Geclosporin

Modify Date: 2024-01-12 05:14:36

Geclosporin structure	Common Name	Geclosporin
	CAS Number	74436-00-3	Molecular Weight	1216.64000
	Density	1.013g/cm3	Boiling Point	1297.8ºC at 760 mmHg
	Molecular Formula	C₆₃H₁₁₃N₁₁O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	738.7ºC

Name	Geclosporin
Synonym	More Synonyms

Density	1.013g/cm3
Boiling Point	1297.8ºC at 760 mmHg
Molecular Formula	C₆₃H₁₁₃N₁₁O₁₂
Molecular Weight	1216.64000
Flash Point	738.7ºC
Exact Mass	1215.86000
PSA	278.80000
LogP	4.53960
Index of Refraction	1.467

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4130000

CHEMICAL NAME :: Cyclosporin A, 7-L-norvaline-

CAS REGISTRY NUMBER :: 74436-00-3

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C63-H113-N11-O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes

REFERENCE :: TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994

Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)

cyclosporin G

(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)

Cyclosporin A,7-L-norvaline

Cyclosporin Impurity 7