CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SP5250000
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CHEMICAL NAME :
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Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-
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CAS REGISTRY NUMBER :
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7456-24-8
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C19-H25-N3-O2-S2
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MOLECULAR WEIGHT :
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391.59
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WISWESSER LINE NOTATION :
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T C666 BN ISJ B1Y1&N1&1 ESWN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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740 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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190 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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475 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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600 mg/kg
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SEX/DURATION :
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female 9-14 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,381,1970
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