Boc-Hyp-OMe

Modify Date: 2024-01-02 15:40:13

Boc-Hyp-OMe Structure
Boc-Hyp-OMe structure
 Common Name Boc-Hyp-OMe
CAS Number 74844-91-0 Molecular Weight 245.272
Density 1.2±0.1 g/cm3 Boiling Point 335.2±42.0 °C at 760 mmHg
Molecular Formula C11H19NO5 Melting Point 92-96 °C(lit.)
MSDS Chinese USA Flash Point 156.6±27.9 °C

 Use of Boc-Hyp-OMe


Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

 Names

Name N-Boc-trans-4-Hydroxy-L-proline methyl ester
Synonym More Synonyms

 Boc-Hyp-OMe Biological Activity

Description Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 335.2±42.0 °C at 760 mmHg
Melting Point 92-96 °C(lit.)
Molecular Formula C11H19NO5
Molecular Weight 245.272
Flash Point 156.6±27.9 °C
Exact Mass 245.126328
PSA 76.07000
LogP -0.25
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.501
Storage condition 2~8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester
N-BOC-transydro-L-prolinemethylester
1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate
N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER
N-BOC-L-Hydroxyproline methyl ester
1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate
BOC-HYDROXYPROLINE-OME
N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester
BOC-L-4-HYDROXYPROLINE METHYL ESTER
N-Boc-trans-hydro-L-prolinemethylester
N-Boc-cis-4-Hydroxy-L-prolinem ethylester
N-Boc-trans-4-Hydroxy-L-prolinemethylester
Boc-Hyp-Ome
(2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
MFCD00076981
BOC-L-HYDROXYPROLINE METHYL ESTER
BOC-L-T-4-HYDROXYPROLINE METHYL ESTER
Boc-trans-4-hydroxy-L-proline methyl ester
N-Boc-cis-4-hydroxy-L-proline methyl ester
Boc-cis-Hyp-OMe
cis-Boc-Hyp-OMe
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