OR-486

Modify Date: 2025-08-26 18:35:15

OR-486 structure	Common Name	OR-486
	CAS Number	7659-29-2	Molecular Weight	200.10600
	Density	1.819g/cm3	Boiling Point	354.5ºC at 760 mmHg
	Molecular Formula	C₆H₄N₂O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	162.2ºC

Use of OR-486

3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex[1][2][3].

Name	3,5-dinitrobenzene-1,2-diol
Synonym	More Synonyms

Description	3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9. [2]. Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43(3):493-502. [3]. Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum(VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63(3):654-60.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9.

[2]. Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43(3):493-502.

[3]. Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum(VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63(3):654-60.

Density	1.819g/cm3
Boiling Point	354.5ºC at 760 mmHg
Molecular Formula	C₆H₄N₂O₆
Molecular Weight	200.10600
Flash Point	162.2ºC
Exact Mass	200.00700
PSA	132.10000
LogP	1.96060
Index of Refraction	1.712
InChIKey	VDCDWNDTNSWDFJ-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1cc(O)c(O)c([N+](=O)[O-])c1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ8947010

CHEMICAL NAME :: 1,2-Benzenediol, 3,5-dinitro-

CAS REGISTRY NUMBER :: 7659-29-2

BEILSTEIN REFERENCE NO. :: 2217246

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H4-N2-O6

MOLECULAR WEIGHT :: 200.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	CZ8947010

1,2-Benzenediol...

CAS#:635-67-6

OR-486

CAS#:7659-29-2

Literature: Journal of the Chemical Society, , p. 1868

N/A

CAS#:89563-21-3

~93%

OR-486

CAS#:7659-29-2

Literature: Spyroudis, Spyros; Varvoglis, Anastasios Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 2 p. 135 - 137

N/A

CAS#:89563-18-8

~33%

OR-486

CAS#:7659-29-2

Literature: Spyroudis, Spyros; Varvoglis, Anastasios Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 2 p. 135 - 137

2,4-Dinitrophenol

CAS#:51-28-5

OR-486

CAS#:7659-29-2

Literature: Tetrahedron, , vol. 26, p. 255 - 265

6-Methoxy-2,4-d...

CAS#:4097-63-6

OR-486

CAS#:7659-29-2

Literature: Journal of the Chemical Society, , vol. 103, p. 1489 Journal fuer Praktische Chemie (Leipzig), , vol. <2>88, p. 796 Bulletin de la Societe Chimique de France, , vol. <4>13, p. 989 Chem. Zentralbl., , vol. 85, # I p. 460

(2-hydroxy-3,5-...

CAS#:89563-26-8

OR-486

CAS#:7659-29-2

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 135 - 137

Hydrochloric acid

CAS#:7647-01-0

6-Methoxy-2,4-d...

CAS#:4097-63-6

OR-486

CAS#:7659-29-2

Literature: Journal of the Chemical Society, , vol. 103, p. 1489 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 88, p. 787 Bulletin de la Societe Chimique de France, , vol. <4> 13, p. 982 Chem. Zentralbl., , vol. 85, # I p. 460

2-(2-hydroxy-3,...

CAS#:861612-12-6

Hydrogen bromide

CAS#:10035-10-6

OR-486

CAS#:7659-29-2

Literature: Bulletin de la Societe Chimique de France, , vol. <4> 5, p. 510

Precursor 7
CAS#:635-67-6 1,2-Benzenediol... CAS#:51-28-5 2,4-Dinitrophenol CAS#:4097-63-6 6-Methoxy-2,4-d... CAS#:89563-26-8 (2-hydroxy-3,5-...
CAS#:7647-01-0 Hydrochloric acid CAS#:861612-12-6 2-(2-hydroxy-3,... CAS#:10035-10-6 Hydrogen bromide
DownStream 2
CAS#:59820-95-0 5,7-dinitro-2,3... CAS#:70187-40-5 2-(2-hydroxy-3,...

UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset.

Neuropharmacology 82 , 76-87, (2014)

L-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease (PD), but its long-term administration is complicated by wearing-off and dyskinesia. UWA-101, a dual, equi...

Oxidative deamination of noradrenaline in human blood vessels.

J. Neural Transm. Suppl. 32 , 395-404, (1990)

Human vascular tissue (saphenous vein and uterine artery) was incubated with tritiated noradrenaline. In both vessels, oxidative deamination predominated over O-methylation. Deamination was due to the...

(−)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity

Arch. Biochem. Biophys. 573 , 84-91, (2015)

[Display omitted]

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN

Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity

Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN

Total 199, Current Page 1 of 20

3,5-Dinitropyrocatechol

4,6-dinitro-o-cresol

Pyrocatechol,3,5-dinitro

MFCD00069263

3,5-dinitrocatechol

3,5-Dinitro-1,2-benzenediol

1,2-Benzenediol,3,5-dinitro

OR-486

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OR-486Bioassay

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.