NSC-77053

Modify Date: 2025-08-20 11:25:09

NSC-77053 Structure
NSC-77053 structure
 Common Name NSC-77053
CAS Number 77308-57-7 Molecular Weight 314.33400
Density 1.315g/cm3 Boiling Point 586.6ºC at 760 mmHg
Molecular Formula C21H14O3 Melting Point N/A
MSDS N/A Flash Point 322.6ºC

 Use of NSC-77053


NSC-77053 is a potent BoNT/E inhibitor with an IC50 and a Ki of 2.4 μM and 1.29 μM, respectively[1].

 Names

Name 2-(9H-fluorene-2-carbonyl)benzoic acid

 NSC-77053 Biological Activity

Description NSC-77053 is a potent BoNT/E inhibitor with an IC50 and a Ki of 2.4 μM and 1.29 μM, respectively[1].
Related Catalog
Target

IC50: 2.4 μM (BoNT/E)[1]

References

[1]. Yuchen Zhou, et al. Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity. Bioorg Med Chem. 2016 Oct 15;24(20):4875-4889.  

 Chemical & Physical Properties

Density 1.315g/cm3
Boiling Point 586.6ºC at 760 mmHg
Molecular Formula C21H14O3
Molecular Weight 314.33400
Flash Point 322.6ºC
Exact Mass 314.09400
PSA 54.37000
LogP 4.18700
Index of Refraction 1.682

 Synthetic Route

Phthalic anhydride structure

Phthalic anhydride

CAS#:85-44-9

9H FLUORENE structure

9H FLUORENE

CAS#:86-73-7

~79%

NSC-77053 Structure

NSC-77053

CAS#:77308-57-7

Literature: Guilhemat, Robert; Pereyre, Michel; Petraud, Michel Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 7-8 p. 334 - 344
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Chemsrc provides NSC-77053(CAS#:77308-57-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of NSC-77053 are included as well.>> amp version: NSC-77053

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