NSC-77053

Modify Date: 2024-02-01 19:13:15

NSC-77053 Structure
NSC-77053 structure
Common Name NSC-77053
CAS Number 77308-57-7 Molecular Weight 314.33400
Density 1.315g/cm3 Boiling Point 586.6ºC at 760 mmHg
Molecular Formula C21H14O3 Melting Point N/A
MSDS N/A Flash Point 322.6ºC

 Use of NSC-77053


NSC-77053 is a potent BoNT/E inhibitor with an IC50 and a Ki of 2.4 μM and 1.29 μM, respectively[1].

 Names

Name 2-(9H-fluorene-2-carbonyl)benzoic acid

 NSC-77053 Biological Activity

Description NSC-77053 is a potent BoNT/E inhibitor with an IC50 and a Ki of 2.4 μM and 1.29 μM, respectively[1].
Related Catalog
Target

IC50: 2.4 μM (BoNT/E)[1]

References

[1]. Yuchen Zhou, et al. Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity. Bioorg Med Chem. 2016 Oct 15;24(20):4875-4889.  

 Chemical & Physical Properties

Density 1.315g/cm3
Boiling Point 586.6ºC at 760 mmHg
Molecular Formula C21H14O3
Molecular Weight 314.33400
Flash Point 322.6ºC
Exact Mass 314.09400
PSA 54.37000
LogP 4.18700
Index of Refraction 1.682

 Synthetic Route

~79%

NSC-77053 Structure

NSC-77053

CAS#:77308-57-7

Literature: Guilhemat, Robert; Pereyre, Michel; Petraud, Michel Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 7-8 p. 334 - 344
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