(Pyr6,Pro9)-Substance P (6-11)

Modify Date: 2024-01-28 17:38:39

(Pyr6,Pro9)-Substance P (6-11) structure	Common Name	(Pyr6,Pro9)-Substance P (6-11)
	CAS Number	79775-19-2	Molecular Weight	850.87400
	Density	1.255g/cm3	Boiling Point	1189.4ºC at 760 mmHg
	Molecular Formula	C₃₉H₅₀N₁₀O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	673.1ºC

Use of (Pyr6,Pro9)-Substance P (6-11)

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1].

Name	[Pyr6,Pro9]-Substance P (6-11)
Synonym	More Synonyms

Description	Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	Kd: 0.55 ± 0.03 nM (NK1 receptor)[1]
In Vitro	Septide increases inositol phosphate levels (4-6-fold) in NK1 receptor expressed CHO cells[2].
References	[1]. Hastrup H, Schwartz TW. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS Lett. 1996 Dec 16;399(3):264-6. [2]. Pradier L, Mayaux JF, et al. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93.

[GLP6,PRO9] SUBSTANCE P (6-11)

PYR-PHE-PHE-PRO-LEU-MET-NH2

SEPTIDE

PYR-FFPLM

[pGlu6,Pro9]substance P-(6-11)

[Glp6,L-Pro9]SP(6-11)

PGLU-PHE-PHE-PRO-LEU-MET-NH2

(PYR6,PRO9)-SUBSTANCE P (6-11)

GLP-PHE-PHE-PRO-LEU-MET-NH2

[pGlu6,Pro9]subustance P(6-11)

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