ZZW-115(ZZW115
Modify Date: 2024-01-13 18:44:03
ZZW-115(ZZW115 structure
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Common Name | ZZW-115(ZZW115 | ||
|---|---|---|---|---|
| CAS Number | 801991-87-7 | Molecular Weight | 464.595 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H31F3N4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZZW-115(ZZW115ZZW-115 (ZZW115, ZZW 115) is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation; demonstrates antitumor activity on a panel of 11 primary PDAC-derived cells and it was found to be efficient to kill the cancer cells with IC50 in the range from 0.84 μM (ANOR) to 4.93 μM (HN14), also inhibits the growth of other tumors-derived cells (IC50=0.42 μM (Hep2G cells) to 7.75 μM (SaO-2 cells)); induces pancreatic cell death by necrosis and apoptosis and inhibits the growth pancreatic xenografted tumors in vivo. |
| Name | ZZW-115 |
|---|
| Description | ZZW-115 (ZZW115, ZZW 115) is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation; demonstrates antitumor activity on a panel of 11 primary PDAC-derived cells and it was found to be efficient to kill the cancer cells with IC50 in the range from 0.84 μM (ANOR) to 4.93 μM (HN14), also inhibits the growth of other tumors-derived cells (IC50=0.42 μM (Hep2G cells) to 7.75 μM (SaO-2 cells)); induces pancreatic cell death by necrosis and apoptosis and inhibits the growth pancreatic xenografted tumors in vivo. |
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| References | References 1. Santofimia-Castaño P, et al. J Clin Invest. 2019 Mar 28;130. pii: 127223. View Related Products by Target Other Targets |
| Molecular Formula | C24H31F3N4S |
|---|---|
| Molecular Weight | 464.595 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ZZW-115
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: ZZW-115
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: ZZW-115
- Price: $650.0/100mg $1250.0/250mg $2500.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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