TRV056

Modify Date: 2024-01-09 21:57:33

TRV056 Structure
TRV056 structure
Common Name TRV056
CAS Number 812644-79-4 Molecular Weight 1103.23
Density N/A Boiling Point N/A
Molecular Formula C52H74N14O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TRV056


TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].

 Names

Name TRV056

 TRV056 Biological Activity

Description TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].
Related Catalog
In Vitro TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1].
References

[1]. Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11.

 Chemical & Physical Properties

Molecular Formula C52H74N14O13
Molecular Weight 1103.23