5-Methyluridine-d4

Modify Date: 2024-01-14 22:37:57

5-Methyluridine-d4 Structure
5-Methyluridine-d4 structure
Common Name 5-Methyluridine-d4
CAS Number 82845-85-0 Molecular Weight 262.25300
Density N/A Boiling Point N/A
Molecular Formula C10H10D4N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Methyluridine-d4


5-Methyluridine-d4 is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].

 Names

Name 6-deuterio-1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trideuteriomethyl)pyrimidine-2,4-dione
Synonym More Synonyms

 5-Methyluridine-d4 Biological Activity

Description 5-Methyluridine-d4 is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Yang TH, et al. Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55(2):224-31.  

 Chemical & Physical Properties

Molecular Formula C10H10D4N2O6
Molecular Weight 262.25300
Exact Mass 262.11000
PSA 124.78000

 Synonyms

5-Methyl Uridine-d4