Trimetrexate glucuronate
Modify Date: 2024-06-13 00:46:25
Trimetrexate glucuronate structure
|
Common Name | Trimetrexate glucuronate | ||
|---|---|---|---|---|
| CAS Number | 82952-64-5 | Molecular Weight | 563.55700 | |
| Density | 1.305 g/cm3 | Boiling Point | 647ºC at 760 mmHg | |
| Molecular Formula | C25H33N5O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 345.1ºC | |
Use of Trimetrexate glucuronateTrimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential anti-tumour activity[1]. |
| Name | CI 898 trihydrochloride,5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential anti-tumour activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Trimetrexate glucuronate (0.05-1 μM 6 h) results in a decrease in adenosine and guanosine acids and a significant increase in the pyrimidine nucleotide such as CTP, UTP of WI-L2 human lymphoblastoid cells in a dose-dependent manner[1]. Trimetrexate glucuronate (1 μM, 2 h) can reduce the level of dTTP by 29%, also decrease in the dGTP and dATP, while cause extensive inhibition of deoxyuridine incorporation into DNA in L1210 mouse leukemia cells[1]. |
| In Vivo | Trimetrexate glucuronate (i.p., 100-225 mg/kg, daily, day 1, 5, 9) has antitumor activity in inbred DBA/2 mice with L1210 leukemia[1]. Animal Model: Inbred DBA/2 mice with L1210 leukemia[1] Dosage: 100, 150, 225 mg/kg Administration: Intraperitoneal injection; daily; day 1, 5, 9 Result: Showed the maximum lifespan T/C value of 171%. Animal Model: C57BL/6 mice with M5076 tumor[1] Dosage: 38, 62 mg/kg Administration: Intraperitoneal injection; daily; 1-9 days Result: Showed toxic (>10% early deaths) at high dose of 62 mg/kg and inactive (Lifespan T/C <130%) at lower dose of 38 mg/kg. |
| References |
| Density | 1.305 g/cm3 |
|---|---|
| Boiling Point | 647ºC at 760 mmHg |
| Molecular Formula | C25H33N5O10 |
| Molecular Weight | 563.55700 |
| Flash Point | 345.1ºC |
| Exact Mass | 563.22300 |
| PSA | 244.99000 |
| LogP | 0.84680 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| CI 898 dihydrochloride |
| CI 898 TRIHYDROCHLORIDE |
| Trimetrexate glucuronate |