Chrysomycin B

Modify Date: 2024-01-17 23:43:48

Chrysomycin B Structure
Chrysomycin B structure
Common Name Chrysomycin B
CAS Number 83852-56-6 Molecular Weight 496.506
Density 1.4±0.1 g/cm3 Boiling Point 784.0±60.0 °C at 760 mmHg
Molecular Formula C27H28O9 Melting Point N/A
MSDS Chinese USA Flash Point 265.9±26.4 °C

 Use of Chrysomycin B


Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. Chrysomycin B causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B suppresses the growth of transplantable tumors in mice.

 Names

Name Chrysomycin B
Synonym More Synonyms

 Chrysomycin B Biological Activity

Description Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. Chrysomycin B causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B suppresses the growth of transplantable tumors in mice.
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 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 784.0±60.0 °C at 760 mmHg
Molecular Formula C27H28O9
Molecular Weight 496.506
Flash Point 265.9±26.4 °C
Exact Mass 496.173340
PSA 138.82000
LogP 4.99
Appearance of Characters solid
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.663
Storage condition 2-8°C
Water Solubility DMF: soluble

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles4

More Articles
Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.

Nat. Prod. Rep. 29(2) , 264-325, (2012)

Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativit...

A colorimetric microassay for the detection of agents that interact with DNA.

J. Nat. Prod. 55(11) , 1582-7, (1992)

A simple microtiter assay for the detection of compounds that bind DNA is described. Agents that displace methyl green from DNA are detected spectrophotometrically by a decrease in absorbance at 630 n...

The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A.

J. Antibiot. 35(9) , 1194-201, (1982)

The yellow antibiotic chrysomycin, isolated in crystalline form in 1955, is found to consist of two closely related components, a major one, chrysomycin A, and a minor one, chrysomycin B. They differ ...

 Synonyms

1,5-Anhydro-6-deoxy-1-(1-hydroxy-10,12-dimethoxy-8-methyl-6-oxo-6H-dibenzo[c,h]chromen-4-yl)-3-C-methylhexitol
Hexitol, 1,5-anhydro-6-deoxy-1-C-(1-hydroxy-10,12-dimethoxy-8-methyl-6-oxo-6H-benzo[d]naphtho[1,2-b]pyran-4-yl)-3-C-methyl-
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