4-Methylhistamine hydrochloride

Modify Date: 2025-11-25 12:56:22

4-Methylhistamine hydrochloride structure	Common Name	4-Methylhistamine hydrochloride
	CAS Number	84103-51-5	Molecular Weight	161.63
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₁₂ClN₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4-Methylhistamine hydrochloride

4-Methylhistamine (hydrochloride) is a potent, high affinity H4 receptor agonist Ki of 7 nM. 4-Methylhistamine (hydrochloride) displays more than 100-fold selectivity over other human histamine receptor subtypes[1].

Name	2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride

Description	4-Methylhistamine (hydrochloride) is a potent, high affinity H4 receptor agonist Ki of 7 nM. 4-Methylhistamine (hydrochloride) displays more than 100-fold selectivity over other human histamine receptor subtypes[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Lim HD, et.al. Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21.

Molecular Formula	C₆H₁₂ClN₃
Molecular Weight	161.63
InChIKey	IRQCBSLSHHBBIT-UHFFFAOYSA-N
SMILES	Cc1[nH]cnc1CCN.Cl

Name: Thermal Shift Assay. Domain start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL4650107

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Thermal Shift Assay. Domain: start/stop: E122-S403
Source: ChEMBL
Target: Aurora kinase A
External Id: CHEMBL5068164

Name: Thermal Shift Assay. Domain: start/stop: M1-K294
Source: ChEMBL
Target: Casein kinase I isoform delta
External Id: CHEMBL5064448

Name: Incucyte cell viability with HEK293T
Source: ChEMBL
Target: HEK-293T
External Id: CHEMBL5058565

Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060732

Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589

Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015

Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209826

Name: GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Conc...
Source: ChEMBL
Target: Glucagon-like peptide 1 receptor
External Id: CHEMBL5209829

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4-Methylhistamine hydrochloride

Use of 4-Methylhistamine hydrochloride

Names

4-Methylhistamine hydrochloride Biological Activity

Chemical & Physical Properties

4-Methylhistamine hydrochlorideBioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.