(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one

Modify Date: 2024-01-12 18:51:14

(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one structure	Common Name	(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one
	CAS Number	84638-48-2	Molecular Weight	300.3
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one

LPRP-Et-97543 is a potent anti-HBV agent. LPRP-Et-97543 reduces Core, S, and preS but not X promoter activities. LPRP-Et-97543 can be used for acute and chronic HBV infections research[1].

Name	(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one

Description	LPRP-Et-97543 is a potent anti-HBV agent. LPRP-Et-97543 reduces Core, S, and preS but not X promoter activities. LPRP-Et-97543 can be used for acute and chronic HBV infections research[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	LPRP-Et-97543 (0.625-40 μg/ml; 3 days) causes cytotoxic effects at doses >10 μg/ml in HepG2.2.15 and HBV-transfected Huh7 cells[1]. LPRP-Et-97543 (2.5-10 μg/ml; 3 days) has inhibitory effects on HBsAg and HBeAg secretions. And the HBeAg inhibition rate is higher than the HBsAg inhibition rate in HepG2.2.15 cells[2]. LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) significantly reduces both precore/pregenomic and major S/preS RNA with the LPRP-Et-97543 inhibition potential higher on surface RNA than on the precore/pregenomic RNA[2]. LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) potently reduces intracellular LHBsAg and HBcAg protein levels compared to vehicle controls. Additionally, LPRP-Et-97543 potently inhibits the replication HBV DNAlevel in HBV transfected Huh7 cells[2]. LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) reduces nuclear p65/p50 NF-κB protein expression and reduces phosphorylated NF-κBp65 in Huh7 cells[2]. Western Blot Analysis[1] Cell Line: Huh7 cells with or without pHBV1.2 Concentration: 2.5-10 μg/ml Incubation Time: 2 days Result: Decreased nuclear and nuclear p-p65 expression and increased cytoplasmic IκBα expression.
References	[1]. Tsurng-Juhn Huang, et al. Anti-viral effect of a compound isolated from Liriope platyphylla against hepatitis B virus in vitro.Virus Res. 2014 Nov 4;192:16-24. [2]. Yi-Hang Wu, et al. Naturally derived anti-hepatitis B virus agents and their mechanism of action. World J Gastroenterol. 2016 Jan 7;22(1):188-204.

Molecular Formula	C₁₇H₁₆O₅
Molecular Weight	300.3
Exact Mass	300.099774

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one
Price: Negotiable
Purity: 95.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: LPRP-Et-97543
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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