BX517
Modify Date: 2024-01-10 14:21:04
BX517 structure
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Common Name | BX517 | ||
|---|---|---|---|---|
| CAS Number | 850717-64-5 | Molecular Weight | 282.29700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H14N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BX517BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM. |
| Name | Urea, N-[2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl] |
|---|---|
| Synonym | More Synonyms |
| Description | BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM. |
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| Related Catalog | |
| Target |
IC50: 6 nM (PDK1) |
| In Vitro | BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM[1]. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases[2]. |
| References |
| Molecular Formula | C15H14N4O2 |
|---|---|
| Molecular Weight | 282.29700 |
| Exact Mass | 282.11200 |
| PSA | 100.01000 |
| LogP | 3.29940 |
| Storage condition | 2-8℃ |
| 5-Ureido-3-[1-(pyrrol-2-yl)ethylidene]indolin-2-one |
| Urea, [2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]- |
| PDK-1 INHIBITOR II |
| BX517 |