ST 198

Modify Date: 2024-01-12 15:24:54

ST 198 Structure
ST 198 structure
Common Name ST 198
CAS Number 854924-64-4 Molecular Weight 334.45
Density N/A Boiling Point N/A
Molecular Formula C22H26N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ST 198


ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease[1].

 Names

Name N-[4-(3,4-dihydro-1H-isoquinolin-2-yl)butyl]-3-phenylprop-2-enamide

 ST 198 Biological Activity

Description ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease[1].
Related Catalog
In Vitro ST 198 可以在对 D3R 具有选择性的剂量下阻断尼古丁诱导的 CPP 的表达[1]。
In Vivo ST 198 (p.o.; 3, 30, 100 mg/kg) 抑制尼古丁 CPPs 的表达[1]。 Animal Model: Rats[1]. Dosage: 3, 30, 100 mg/kg Administration: p.o Result: Displayed nicotine-induced CPP.
References

[1]. Le Foll B, et al. Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects. Neuropsychopharmacology. 2005;30(4):720-730.  

 Chemical & Physical Properties

Molecular Formula C22H26N2O
Molecular Weight 334.45
Exact Mass 334.20500
PSA 35.83000
LogP 4.43270
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