Cogentin

Modify Date: 2024-01-04 11:05:57

Cogentin structure	Common Name	Cogentin
	CAS Number	86-13-5	Molecular Weight	307.42900
	Density	1.11g/cm3	Boiling Point	409ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₅NO	Melting Point	N/A
	MSDS	N/A	Flash Point	120.1ºC

Use of Cogentin

Benztropine mesylate is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].

Name	benzatropine
Synonym	More Synonyms

Description	Benztropine mesylate is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	5 μM (MDA-MB-231)
In Vitro	Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne[1]. Benztropine mesylate inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors[1]. Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination[1]. Cell Viability Assay[1] Cell Line: MDA-MB-231 Concentration: 0, 0.1, 0.625, 1.25, 2.5, 5, 10 μM Incubation Time: 72 hours Result: Inhibited cells growth of MDA-MB-231 with IC50 ~5.0 μM. Cell Viability Assay[1] Cell Line: MDA-MB-231 Concentration: 0, 1, 2, 5 μM Incubation Time: 4-6 days Result: Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.
In Vivo	Benztropine mesylate (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model[1]. Animal Model: Balb/c mice bearing 4T1 breast tumors[1] Dosage: 1.5 mg/kg Administration: Injection; 3 weeks Result: Reduced the tumor size and weight significantly without body weight changing.
References	[1]. Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022. [2]. Santosh S Kulkarni, et al. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorg Med Chem. 2006 Jun 1;14(11):3625-34.

Density	1.11g/cm3
Boiling Point	409ºC at 760 mmHg
Molecular Formula	C₂₁H₂₅NO
Molecular Weight	307.42900
Flash Point	120.1ºC
Exact Mass	307.19400
PSA	12.47000
LogP	4.35570
Index of Refraction	1.604

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3100000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropane, 3-alpha-(diphenylmethoxy)-

CAS REGISTRY NUMBER :: 86-13-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H25-N-O

MOLECULAR WEIGHT :: 307.47

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOYR&R -ALL ALPHA

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,215,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,215,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3957 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 103 (estimated) No. of Female Employees: 52 (estimated)

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Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

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Literature: Merck and Co.Inc. Patent: US2706198 , 1952 ;

N/A

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Cogentin

CAS#:86-13-5

Literature: Merck and Co.Inc. Patent: US2595405 , 1949 ;

3α-benzhydrylox...

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~82%

Cogentin

CAS#:86-13-5

Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

Benaztropine

benzotropine

exo-Benztropine

tropine benzohydryl ether

DC Chemicals Limited
China
Product Name: Cogentin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
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