Gastrazole
Modify Date: 2025-08-25 18:04:29
Gastrazole structure
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Common Name | Gastrazole | ||
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| CAS Number | 862583-15-1 | Molecular Weight | 687.62500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H32FN5Na2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GastrazoleGastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2]. |
| Name | disodium,5-[[(2S)-2-[[6-(cycloheptylmethylcarbamoyl)-1H-benzimidazole-5-carbonyl]amino]-3-(2-fluorophenyl)propanoyl]amino]benzene-1,3-dicarboxylate |
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| Synonym | More Synonyms |
| Description | Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2]. |
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| Related Catalog | |
| Target |
CCK2/gastrin receptor[1] |
| In Vivo | Gastrazole (0.15-3 μmol/kg; i.v.) dose-dependently inhibits the Pentagastrin-stimulated gastric acid secretion[2]. Animal Model: Male Sprague-Dawley rats with a gastric fistula[2] Dosage: 0.15, 0.3, 3 mg/kg Administration: Intravenous administration Result: Dose-dependently inhibited Pentagastrin-stimulation acid secretion by maximally 73%. |
| References |
| Molecular Formula | C34H32FN5Na2O7 |
|---|---|
| Molecular Weight | 687.62500 |
| Exact Mass | 687.20800 |
| PSA | 206.71000 |
| LogP | 6.32250 |
| unii-55tzm8f95p |