Tecarfarin

Modify Date: 2024-01-24 07:01:56

Tecarfarin Structure
Tecarfarin structure
Common Name Tecarfarin
CAS Number 867257-26-9 Molecular Weight 460.32300
Density N/A Boiling Point N/A
Molecular Formula C21H14F6O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tecarfarin


Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2].

 Names

Name (1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yl) 4-[(4-hydroxy-2-oxochromen-3-yl)methyl]benzoate
Synonym More Synonyms

 Tecarfarin Biological Activity

Description Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2].
Related Catalog
Target

VKOR[1]

References

[1]. Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117(11):2009-2011.

[2]. Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126(5):e383-8.

 Chemical & Physical Properties

Molecular Formula C21H14F6O5
Molecular Weight 460.32300
Exact Mass 460.07500
PSA 76.74000
LogP 5.12950

 Synonyms

tecarfarin
ati-5923
unii-wn1479yt50
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