TLQP-21 (mouse, rat) trifluoroacetate salt

Modify Date: 2024-01-10 01:16:33

TLQP-21 (mouse, rat) trifluoroacetate salt Structure
TLQP-21 (mouse, rat) trifluoroacetate salt structure
Common Name TLQP-21 (mouse, rat) trifluoroacetate salt
CAS Number 869988-94-3 Molecular Weight 2432.75000
Density N/A Boiling Point N/A
Molecular Formula C107H170N40O26 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TLQP-21 (mouse, rat) trifluoroacetate salt


TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2].

 Names

Name tlqp 21
Synonym More Synonyms

  Biological Activity

Description TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2].
Related Catalog
In Vitro TLQP-21 is a peptide of 21 amino acids. At a dose of 3 μM TLQP-21 induces up to ~69% of the corresponding contraction promoted by acetylcholine[1][2].
References

[1]. Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130.

[2]. Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753.

 Chemical & Physical Properties

Molecular Formula C107H170N40O26
Molecular Weight 2432.75000
Exact Mass 2431.32000
PSA 1047.58000
LogP 0.26540

 Synonyms

H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH