TCMDC-125457

Modify Date: 2024-01-22 20:41:27

TCMDC-125457 Structure
TCMDC-125457 structure
Common Name TCMDC-125457
CAS Number 872113-12-7 Molecular Weight 399.83
Density N/A Boiling Point N/A
Molecular Formula C19H18ClN5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TCMDC-125457


TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.

 Names

Name TCMDC-125457

 TCMDC-125457 Biological Activity

Description TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
References

[1]. Chia W, et al. High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372.

 Chemical & Physical Properties

Molecular Formula C19H18ClN5O3
Molecular Weight 399.83
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