Iobenguane sulfate
Modify Date: 2024-01-07 20:03:01
Iobenguane sulfate structure
|
Common Name | Iobenguane sulfate | ||
|---|---|---|---|---|
| CAS Number | 87862-25-7 | Molecular Weight | 648.25800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H10IN3.1/2H2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Iobenguane sulfateIobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)[1][2]. |
| Name | 1-(3-Iodobenzyl)guanidine sulfate (2:1) |
|---|
| Description | Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines[1]. Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range[2]. Cell Proliferation Assay[1] Cell Line: 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells Concentration: 2, 20μg/ml Incubation Time: 72 hours Result: Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth. |
| In Vivo | Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity[1]. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed[1]. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg[1]. Animal Model: DBA/2 (L1210)) mice[1] Dosage: i.p.; daily on days 3-6 Administration: 20 mg/kg Result: Considerable prolongation of survival and some cures were obtained. |
| References |
| Molecular Formula | C8H10IN3.1/2H2O4S |
|---|---|
| Molecular Weight | 648.25800 |
| Exact Mass | 647.95100 |
| PSA | 206.78000 |
| LogP | 5.35840 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Iobenguane sulfate
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: Iobenguane sulfate
- Price: $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Iobenguane sulfate
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3-IODOBENZYL-GUANIDINE HEMISULFATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
Get all suppliers and price by the below link:
Price: ￥1650/1 mg
Reference only. check more Iobenguane sulfate price