R 268712
Modify Date: 2024-02-01 18:52:27
R 268712 structure
|
Common Name | R 268712 | ||
|---|---|---|---|---|
| CAS Number | 879487-87-3 | Molecular Weight | 363.388 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 576.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H18FN5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 302.7±30.1 °C | |
Use of R 268712R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.IC50 value: 2.5 nM [1]Target: ALK5in vitro: R-268712 is a novel and specific inhibitor of activin receptor-like kinase 5 (ALK5), a transforming growth factor β (TGF-β) type I receptor. R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK). R-268712 is a weak inhibitor of p38 MAP kinase (IC50: 12.1 μM).[1]in vivo: Oral administration of R-268712 at doses of 1, 3 and 10 mg/kg also inhibited the development of renal fibrosis in a dose-dependent manner in a unilateral ureteral obstruction (UUO) model. [1] |
| Name | R-268712 |
|---|---|
| Synonym | More Synonyms |
| Description | R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.IC50 value: 2.5 nM [1]Target: ALK5in vitro: R-268712 is a novel and specific inhibitor of activin receptor-like kinase 5 (ALK5), a transforming growth factor β (TGF-β) type I receptor. R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK). R-268712 is a weak inhibitor of p38 MAP kinase (IC50: 12.1 μM).[1]in vivo: Oral administration of R-268712 at doses of 1, 3 and 10 mg/kg also inhibited the development of renal fibrosis in a dose-dependent manner in a unilateral ureteral obstruction (UUO) model. [1] |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.8±50.0 °C at 760 mmHg |
| Molecular Formula | C20H18FN5O |
| Molecular Weight | 363.388 |
| Flash Point | 302.7±30.1 °C |
| Exact Mass | 363.149536 |
| LogP | 2.79 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.675 |
| Storage condition | 2-8℃ |
| 1H-Pyrazole-1-ethanol, 4-[2-fluoro-5-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]- |
| 2-(4-{2-Fluoro-5-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl}-1H-pyrazol-1-yl)ethanol |