HDS 029

Modify Date: 2024-01-24 08:23:10

HDS 029 structure	Common Name	HDS 029
	CAS Number	881001-19-0	Molecular Weight	355.75400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₁ClFN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDS 029

EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively[1].

Name	N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-ynamide
Synonym	More Synonyms

Description	EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	ErbB2:1.1 nM (IC50) ErbB1:0.3 nM (IC50) ErbB4:0.5 nM (IC50) EGFR:2.5 nM (IC50) HER:24 nM (IC50)
References	[1]. Klutchko SR, et al. Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem. 2006 Feb 23;49(4):1475-85.

Molecular Formula	C₁₇H₁₁ClFN₅O
Molecular Weight	355.75400
Exact Mass	355.06400
PSA	83.29000
LogP	4.24520

HMS3229E05

EGFR/ErbB-2/ErbB-4 Inhibitor

IN1346

HDS 029

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HDS 029
Price: Negotiable
Purity: 95.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Hds029
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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