3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

Modify Date: 2024-01-12 15:22:27

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole Structure
3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole structure
Common Name 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
CAS Number 882562-40-5 Molecular Weight 404.270
Density 1.5±0.1 g/cm3 Boiling Point 650.4±65.0 °C at 760 mmHg
Molecular Formula C18H11Cl2N3O2S Melting Point N/A
MSDS N/A Flash Point 347.1±34.3 °C

 Names

Name 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 650.4±65.0 °C at 760 mmHg
Molecular Formula C18H11Cl2N3O2S
Molecular Weight 404.270
Flash Point 347.1±34.3 °C
Exact Mass 402.994904
PSA 73.23000
LogP 4.47
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.709

 Safety Information

HS Code 2933990090

 Synthetic Route

~90%

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole Structure

3-(2,5-Dichloro...

CAS#:882562-40-5

Literature: CELLTECH R and D LIMITED Patent: WO2006/38001 A1, 2006 ; Location in patent: Page/Page column 40 ; WO 2006/038001 A1

~47%

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole Structure

3-(2,5-Dichloro...

CAS#:882562-40-5

Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie Patent: WO2013/14448 A1, 2013 ; Location in patent: Page/Page column 88; 89 ; WO 2013/014448 A1

~66%

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole Structure

3-(2,5-Dichloro...

CAS#:882562-40-5

Literature: Ward, Richard A.; Anderton, Mark J.; Ashton, Susan; Bethel, Paul A.; Box, Matthew; Butterworth, Sam; Colclough, Nicola; Chorley, Christopher G.; Chuaqui, Claudio; Cross, Darren A.E.; Dakin, Les A.; Debreczeni, Judit E.; Eberlein, Cath; Finlay, M. Raymond V.; Hill, George B.; Grist, Matthew; Klinowska, Teresa C.M.; Lane, Clare; Martin, Scott; Orme, Jonathon P.; Smith, Peter; Wang, Fengjiang; Waring, Michael J. Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 7025 - 7048

~%

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole Structure

3-(2,5-Dichloro...

CAS#:882562-40-5

Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie Patent: WO2013/14448 A1, 2013 ; WO 2013/014448 A1

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1H-Indole, 3-(2,5-dichloro-4-pyrimidinyl)-1-(phenylsulfonyl)-
1-(benzenesulfonyl)-3-(2,5-dichloropyrimidin-4-yl)indole
3-(2,5-Dichloro-4-pyrimidinyl)-1-(phenylsulfonyl)-1H-indole
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Price: ¥697/250mg

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