(S)-Mapracorat

Modify Date: 2024-01-09 16:04:41

(S)-Mapracorat structure	Common Name	(S)-Mapracorat
	CAS Number	887375-15-7	Molecular Weight	462.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₆F₄N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (S)-Mapracorat

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

Name	(S)-Mapracorat

Description	(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.
In Vivo	Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.
References	[1]. Bäumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.

Molecular Formula	C₂₅H₂₆F₄N₂O₂
Molecular Weight	462.48

DC Chemicals Limited
China
Product Name: (S)-Mapracorat
Price: $1200.0/100mg $2400.0/250mg $4800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥7150/10 mM * 1 mL in DMSO

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