Melarsomine dihydrochloride

Modify Date: 2026-07-15 23:01:52

Melarsomine dihydrochloride Structure
Melarsomine dihydrochloride structure
Common Name Melarsomine dihydrochloride
CAS Number 89141-50-4 Molecular Weight 501.33300
Density N/A Boiling Point 678.1ºC at 760 mmHg
Molecular Formula C13H23AsCl2N8S2 Melting Point N/A
MSDS N/A Flash Point 363.9ºC

 Use of Melarsomine dihydrochloride


Melarsomine dihydrochloride is a trivalent arsenical compound used as an adulticide. Melarsomine dihydrochloride can be used for the reserach of canine heartworm disease and other helminth infections[1][2].

 Names

Name 2-N-[4-[bis(2-aminoethylsulfanyl)arsanyl]phenyl]-1,3,5-triazine-2,4,6-triamine,dihydrochloride
Synonym More Synonyms

 Melarsomine dihydrochloride Biological Activity

Description Melarsomine dihydrochloride is a trivalent arsenical compound used as an adulticide. Melarsomine dihydrochloride can be used for the reserach of canine heartworm disease and other helminth infections[1][2].
Related Catalog
In Vivo Melarsomine (2.5 mg/kg; deep i.m. injection) combined with Doramectin managed to clear the D. repens infection in dogs[1]. Melarsomine (0.25 mg/kg; deep i.m. injection) can cure T. evansi infection in camels[2]. Melarsomine (0.5 mg/kg; deep i.m. injection) can cure T. evansi infection in dairy cattle in Thailand[2].
References

[1]. Baneth G, et, al. Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet Parasitol. 2002 Apr 30;105(2):173-8.

[2]. Desquesnes M, et, al. An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology. 2011 Aug;138(9):1134-42.

 Chemical & Physical Properties

Boiling Point 678.1ºC at 760 mmHg
Molecular Formula C13H23AsCl2N8S2
Molecular Weight 501.33300
Flash Point 363.9ºC
Exact Mass 500.00800
PSA 206.84000
LogP 2.79640
InChIKey WMZUMAJTJUZEKQ-UHFFFAOYSA-N
SMILES Cl.Cl.NCCS[As](SCCN)c1ccc(Nc2nc(N)nc(N)n2)cc1

 Melarsomine dihydrochlorideBioassay

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Name: Toxicity in Swiss mouse assessed as death at 100 mg/kg, ip administered as single dos...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL4231350
Name: Antitrypanosomal activity against Trypanosoma brucei brucei CMP infected in Swiss mou...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL4231348
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 Synonyms

melaminylthioarsenate
RM 110
melCy
UNII-9CVA716Q71
Cymelarsen
Melaminylthioarsenite
Cymelarsan
Arsonodithious acid,(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)-,bis(2-aminoethyl) ester,dihydrochloride
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