5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI)

Modify Date: 2024-04-07 04:41:15

5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI) structure	Common Name	5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-a-lyxo-hexopyranosyl]oxy]-,hydrochloride, (8S,10S)- (9CI)
	CAS Number	89196-04-3	Molecular Weight	650.07000
	Density	N/A	Boiling Point	842.4ºC at 760 mmHg
	Molecular Formula	C₃₁H₃₆ClNO₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	463.2ºC

Name	5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(4-morpholinyl)-.α.-L-lyxo-hexopyranosyl]oxy]-, hydrochloride, (8S-cis)
Synonym	More Synonyms

Boiling Point	842.4ºC at 760 mmHg
Molecular Formula	C₃₁H₃₆ClNO₁₂
Molecular Weight	650.07000
Flash Point	463.2ºC
Exact Mass	649.19300
PSA	192.52000
LogP	1.11470
InChIKey	INAUWOVKEZHHDM-PEDBPRJASA-N
SMILES	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)CC(O)(C(=O)CO)CC3OC1CC(N2CCOCC2)C(O)C(C)O1.Cl

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9426040

CHEMICAL NAME :: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-(( 2,3,6-trideoxy- 3-(4-morpholinyl)-alpha-lyxo-hexopyranosyl)oxy)-6,8,1 1-trihydroxy-, hydrochloride, (8S-cis)-

CAS REGISTRY NUMBER :: 89196-04-3

LAST UPDATED :: 199303

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C31-H35-N-O12.Cl-H

MOLECULAR WEIGHT :: 650.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Musculoskeletal - other changes Nutritional and Gross Metabolic - dehydration

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-211144

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Musculoskeletal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-211144

Morpholinoadriamycin

(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-10-[(2S,4S,5S,6S)-5-hydroxy-6-methyl-4-morpholin-4-yl-oxan-2-yl]oxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione hydrochloride

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