EAI001
Modify Date: 2024-01-22 10:38:04
EAI001 structure
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Common Name | EAI001 | ||
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| CAS Number | 892772-75-7 | Molecular Weight | 349.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H15N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EAI001EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2]. |
| Name | 2-(1-Oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide |
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| Synonym | More Synonyms |
| Description | EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2]. |
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| Related Catalog | |
| In Vitro | EAI001 (50 μM) binds to EGFR T790M/C797S/V948R that lies deep inside the EGFR towards the ATP binding site and C-helix. EAI001 showed inhibitory activity due to hydrophobic interaction with amino acid Ile759, Leu747, Leu788, Leu777 and Met766[1]. |
| References |
| Molecular Formula | C19H15N3O2S |
|---|---|
| Molecular Weight | 349.41 |
| MFCD30187870 |