LIMK1 inhibitor BMS-4

Modify Date: 2025-08-25 06:33:25

LIMK1 inhibitor BMS-4 structure	Common Name	LIMK1 inhibitor BMS-4
	CAS Number	905298-84-2	Molecular Weight	461.53900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₃N₇O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LIMK1 inhibitor BMS-4

LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].

Name	1-Ethyl-3-{5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4- pyrimidinyl]-1,3-thiazol-2-yl}ure

Description	LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)
Target	LIMK1:7.25 (pIC50) LIMK2:6.87 (pIC50)
In Vitro	LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) 在体外抑制 LIMK 而不影响 A549 细胞存活或增殖[1]。 LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) 在 A549 人肺癌细胞中抑制 LIMK 底物 cofilin 的磷酸化[1]。
References	[1]. Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. [2]. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.

Molecular Formula	C₂₃H₂₃N₇O₂S
Molecular Weight	461.53900
Exact Mass	461.16300
PSA	146.54000
LogP	4.76830
InChIKey	WUCYRTXFXRZKSV-UHFFFAOYSA-N
SMILES	CCNC(=O)Nc1ncc(-c2cc(-c3c(C)cc(OC)cc3C)nc(-c3cnccn3)n2)s1

Name: NCATS Kinetic Aqueous Solubility Profiling
Source: NCGC
Target: N/A
External Id: ADME-solubility1

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr

Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP

Name: Solubility of the compound in phosphate buffer at pH 6.5 by nephelometry
Source: ChEMBL
Target: N/A
External Id: CHEMBL3391334

Name: Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protei...
Source: ChEMBL
Target: LIM domain kinase 1
External Id: CHEMBL3391310

Name: Partition coefficient, log D of the compound at pH 7.4 by HPLC analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL3391336

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.